Utilizing Spatial Biology & PK/PD Data to Optimize Target Discovery, Target-Linker Pairing & Payload Selection for Innovative ADC Discovery

• Leveraging Portrai’s extensive spatial map database (over 120 million cells) to identify optimized tumor-specific coverage for bispecific ADC target discovery and pairing
• Applying a ‘Virtual Tissue Pharmacology’ approach to combine spatial maps of target expression and linker enzyme distribution, designing ADCs with enhanced tumor targeting and reduced developmental risk
• Investigating spatial gene signature shifts pre- and post-ADC treatment to predict payload-specific tumor sensitivity and clinical efficacy

Speakers:

Daeseung Lee

Co-Founder & Chief Executive Officer

Portrai